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Will Inhaled Insulin Really Take Your Breath Away?

by John Walsh, P.A., C.D.E.

The FDA approved the first inhaled version of insulin called Exubera from Pfizer Inc. in January 2006. It became available in September 2006, 84 years after the first insulin injections were given. By October 2007, Pfizer announced it would be dropping Exubera, citing that the drug had failed to gain the acceptance of patients and physicians. While a couple other companies have worked on inhaled insulin, Mannkind Corp is the only company still working on it today.

Actual insulin inhaler

Artist's Concept, 1996

Background

Over the years, various attempts have been made to capture the $3 billion injected insulin market. Three alternative sites of delivery have fared well in the competition: into upper nasal pathways or the lungs and through the stomach.

Delivery of an insulin pill through the stomach has two hurdles to overcome: getting intact insulin molecules past acidity and digestive enzymes in the stomach and intestines, and then opening the intestinal membranes to insulin transport. These problems have stymied researchers for at least 40 years, although a new novel approach discussed below offers some hope.

Delivery of insulin to the small bath towel size area of the upper nasal airways suffers from poor transport across the nasal membranes. Delivery this way requires very large doses of insulin or use of a chemical to enhance insulin transport. Chemicals used to enhance insulin transport often cause nasal irritation and a runny nose. Even a mild cold or stuffiness could easily change the intended insulin dose. About 100 units of insulin must be deposited into the nose to deliver 10 units into the blood. Insulin production costs would seem prohibitive except that a similar ratio applies to lung delivery, a method that is rapidly progressing.

Compared to nasal delivery, transport of insulin through the lungs allows delivery across a surface area the size of a singles tennis court. Absorption into the bloodstream occurs through the thin alveolar walls of the lungs. This appears to be the most promising approach for delivery at this time. However, there is concern about the long-term effects of inhaling a growth protein into the lungs. It is hoped the large surface area over which it is spread will minimize negative effects, but small decreases in oxygen transport have already been noted in some research studies.

Several companies were working on providing inhaled insulin but gave up for numerous reasons.

Mannkind Corporation - Technosphere Insulin System

Technosphere Insulin System

Mannkind is taking part in the inhaled insulin competition with their Technosphere Insulin System, a palm sized inhaler device. According to them, their system allows insulin to be rapidly absorbed into the bloodstream and reach peak levels in 12 to 14 minutes. They attribute this to their carrier molecule and their formulation of a faster acting insulin than is currently on the market. In their system, insulin is loaded onto pH-sensitive carrier particles, dried to a powder and loaded into plastic cartridges and packaged. Due to the aerodynamic properties of the particles, the powder is scattered deep into the lungs when the patient inhales. When these pH sensitive particles come into contact with the neutral pH of the lungs, the particles dissolve immediately, becomes a liquid and absorb into the lungs. The name of the insulin they plan to use is Afrezza. This rapid acting mealtime insulin therapy is being studied for use in adult patients with type 1 and type 2 diabetes. The Afrezza Inhalation Powder is pre-metered into single use dose cartridges and the light, discreet and easy to use Afrezza Inhaler. A new drug application requesting approval to market Afrezza was accepted by the FDA in May 2009. In early 2011, the FDA rejected the drug and required two more clinical trials.

Eli Lilly - AIR Insulin

Eli Lilly was seen as the next company to step into the inhaled insulin market. Its AIR Insulin was expected to be submitted for approval in 2009 but was discontinued in 2008. The AIR Insulin System was undergoing Phase III clinical trials as a potential treatment for Type 1 and Type 2 diabetes. Lilly, developing the product alongside drug delivery specialist Alkermes, had been working on developing an inhaled insulin product since 2001. 

Novo Nordisk

AERX Inhaled Insulin Device

Novo Nordisk was in  Phase III trials for its AERx Insulin Diabetes Management System before shelving it in 2008. Novo Nordisk had partnered with Aradigm to produce an inhaled insulin that used a liquid formulation. Their device used a breath-guidance system that only delivered insulin to the lung when breathing was "correct". It used strips with liquid insulin. This made dosage adjustments possible to the nearest unit. 

Pfizer - Exubera

Exubera Inhaler

Exubera was the first of the inhaled insulins to be released. It was approved for those over 18 years of age with diabetes, but realistically was only appropriate for those with Type 1 who were on larger doses of insulin, such as 60 or more units per day, or those with Type 2 who can tolerate larger doses of insulin. It was a short-acting powder form of insulin that was inhaled before each meal. A long-acting insulin was still needed to be given each day by injection for Type 1's and some Type 2's. To create an inhaler, Pfizer and Aventis collaborated with Nektar Therapeutics (formerly Inhale Therapeutics), a company that specializes in finding delivery solutions for oral, injectable and pulmonary drug administration. The Exubera inhaler weighed about 4 ounces and was about the size of an eyeglass case when closed. It opened to about 12 inches for delivery. The lack of discreet delivery was another issue repeatedly brought up by detractors of the device.

Similar to other inhaled insulins, a number of side effects were reported. They included coughing, shortness of breath, sore throat and dry mouth. Exubera is not approved for smokers or anyone who has smoked in the last six months because almost twice as much of the inhaled insulin can enter the bloodstream and increase the possibility of an overdose. It was also not approved for anyone with a lung disorder, such as asthma, emphysema, or chronic obstructive pulmonary disease. Exercise also increases transport and likelihood of lows.

Exubera Action Times

Another major problem with Exubera was the inability to deliver precise insulin doses. The smallest blister pack available contains the equivalent of 3 units of Regular insulin. A 3 unit dose would make it difficult for many people using insulin to achieve accurate control which is the real goal of any insulin therapy. Using the 1800 Rule for Regular insulin, someone on 60 units of insulin per day would lower their blood sugar about 90 mg/dl (5 mmol) per 3 unit pack, while someone on 30 units a day would drop 180 mg/dl (10 mmol) per pack. Precise control flies out the window with this sledge hammer approach, especially compared to an insulin pump that can deliver one twentieth of a unit with precision.

Exubera was withdrawn from the U.S. market in 2007 due to lack of consumer demand.

Updated date: Mon, 05/26/2014 - 15:20

  • Updated date: Mon, 05/26/2014 - 15:20

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