Diabetes News for Nov. 5, 2000
20 to 22% off on books and scales

Heart Disease Risk And Vitamin E
Take Triglyceride Levels To Heart
Medical Budget May Indicate Diabetes
No Insurance = No Treatment
Advances In E-Health
Fight Hepatitis With Potatoes?
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Heart Disease Risk And Vitamin E

Vitamin E has been shown recently to provide many health benefits. In particular, one recent study indicates that Vitamin E can benefit people with and without diabetes by decreasing the risk of heart disease.Vitamin E protects the heart

One of the many complications of Type 2 diabetes is an increased risk for developing heart disease. Researchers from the University of Texas Southwestern Medical Center at Dallas recently conducted a study to determine whether or not taking a Vitamin E supplement could reduce the risk of heart disease in people with Type 2. Participants in the study were divided into three groups. One group had Type 2 diabetes and heart disease, one group had only Type 2 diabetes, and the last group did not have diabetes or heart disease.

All of the participants had blood tests done at the beginning of the study. They were then given a daily Vitamin E supplement of 1,200 IU. Blood tests were then done after the participants had taken the supplement. A third set of blood tests was conducted two months after the participants stopped taking the supplement.

The results, which are published in the journal Free Radical Biology and Medicine (October 23, 2000), indicate that all three groups benefited from the Vitamin E. Blood levels of C-reactive protein, which is an indicator of inflammation and is associated with an increased risk of heart disease, were measured. C-reactive protein levels were lowered by 30% in the group with heart disease, indicating a decreased risk for heart attack. In addition, blood levels of an inflammatory cytokine which is also linked to heart disease, called IL-6, were reduced by up to 50% in all three groups. These drops would indicate a decreased risk for heart disease.

Researchers hope that the results of the study will indicate that there are ways to decrease the risk for heart disease in everyone, especially for those with Type 2 who are already at an increased risk. High dose vitamin E has long been known to have anti-inflammatory properties. Since many people with diabetes have higher levels of inflammatory proteins and cytokines, and these are believed to be a major cause of the increased risk for heart disease seen in people with diabetes, taking higher doses of vitamin E may have major benefits in reducing heart disease. However, researchers are unsure of how to determine the best dose for each individual.

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Take Triglyceride Levels To Heart

Bypass surgery is rather risky under any circumstances, but the risk for heart attack and death after surgery is even greater when a person has high triglyceride levels.

In a recent issue of Diabetes Care (volume 23, pages 1648-1653, November 2000), researchers from the Cleveland Clinic Foundation in Ohio report on their study that included 1,200 men and women with diabetes who underwent coronary artery bypass surgery.

The researchers found that those participants with high triglyceride levels had lower survival rates after ten years. Also, the risk for death, heart attack, or repeat bypass surgery was one-third higher in people with high triglyceride levels. The researchers also found that women were at greater risk than men, as high triglyceride levels meant a 50% higher risk of heart attack, death, or additional surgery. One reason for this increased risk may relate to the article above. Higher triglyceride levels and the free fatty acids that accompany them are associated with increased inflammation. 

The study indicates that treatment regimens for people with diabetes who have had bypass surgery should include methods for decreasing triglyceride levels.

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Medical Budget May Indicate Diabetes

Although most of the warning signs of diabetes are pretty well-known, a new study indicates that a person's medical bills may also be an early warning sign of an impending diagnosis of diabetes.

The study was conducted by researchers from the Kaiser Permanente Center for Health Research in Portland, Oregon, and is published in the journal Diabetes Care (volume 23, pages 1654-1658, November 2000). The researchers studied medical billing records of people who'd gone to a particular HMO between 1988 and 1995.

Researchers found that those who were diagnosed with Type 2 diabetes had medical bills which averaged $1,205 more per year in the eight years preceding their diagnosis than those who did not have diabetes. In addition, those with Type 2 had bills up to $1,913 higher than those without disease in the three years before their diagnosis. The increased costs are likely due to the discovery of cholesterol problems and high blood pressure which may precede the diagnosis of diabetes.

The study authors hope that this information will lead to an increased focus on early detection of the disease, so that further medical complications and costs can be avoided for people with diabetes.

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No Insurance = No Treatment

For the millions of Americans without health insurance, medical treatment is not a possibility, even when they have a real health condition.

The Journal of the American Medical Association (October 25, 2000) recently published a study conducted by researchers at Harvard. The researchers studied data from surveys completed by 223,128 people. Ten percent of the participants had been without health insurance for at least a year. Seventy percent of these who were in poor health, and half of those who were in fair health, said that they had not gotten checkups or treatment for their health problems. Twenty-six percent of the uninsured participants who had high blood pressure or diabetes had not had a checkup in two years.

Data from the Census Bureau has indicated that 15.5% of the population did not have health insurance last year. The Harvard study indicates that lack of health insurance is a health risk in itself, and one that is clearly faced by many people in America.

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Advances In E-Health

Because of its accessibility and up-to-the-minute information, the internet has become a popular forum for medical news and resources. Especially popular are the sites that allow internet users to create personal health profiles and gain services particular to their needs.

One of the most recently developed personal medical sites is My Lifeguard for Health, which will allow people to access medical information through a medical library, prevention and treatment sections for different health areas, and personalized weekly newsletters which will focus on the individual's health issue of choice.

My Lifeguard for Health is a private label version of a website that has already been established, Building Better Health. The Lifeguard site will allow people to access the content, e-commerce, online pharmacy, and personalized health management tools established by Building Better Health.

The website has been developed by Consumer Health Interactive, which promotes healthcare websites called e-health portals.

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Fight Hepatitis With Potatoes?

Hepatitis B is a virus that can lead to liver disease, cancer, and even death. Although it is faced by people around the world, a cure has not yet been found. There is a vaccine, but it is expensive and therefore unattainable by many people. However, researchers believe they are closer to developing an edible vaccine that would be much more accessible.

The vaccine is being developed by researchers at Cornell University's Boyce Thompson Institute for Plant Research, who published their study in the journal Nature Biotechnology. The scientists are basing their research on the principles of the vaccine currently in use, which is based on an antigen that is produced in yeast. The antigens, which are proteins on a virus or bacteria, act by stimulating the body to produce antibodies. The antibodies then seek out invading cells, which are destroyed by immune cells. The protein HBsAg produces this response, and when it is inserted into yeast, it can be used to create a vaccine for hepatitis B.

The problem with the vaccine in its current form is that it is expensive, and must be refrigerated. This makes distribution difficult. The researchers at Cornell hoped to solve this problem by engineering plants to produce the protein. They genetically engineered potatoes to produce the protein, and then fed the potatoes to mice. The response was promising-- the mice produced antibodies against hepatitis B.

The scientists hope that further research will be conducted, and that an edible vaccine for hepatitis B can one day be widely distributed. Currently, the only oral vaccine in use is for polio, but researchers are developing such vaccines for Type 1 diabetes, cholera, rotavirus, E. coli, and dental cavities.

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