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Future Monitoring

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A.Menarini Diagnostics - Biosensor Semi-Invasive Monitoring, Measures glucose with a minimal breech of the outer skin layers. Continuous Monitoring, Measures glucose at a constant.

A.Menarini Diagnostics is a health care company with a worldwide network of affiliates, partners, and distributors. They have been in the pharmaceutical business for over 100 years, and in the last 30 years has become Italy's largest pharmaceutical R&D company. They released the GlucoDay® S semi-invasive continuous glucose monitor, which is the first system based on a "microdialysis” technique in the world to obtain the CE marking for the Medical Device Directive, which is necessary for the marketing of a product in the European Union.

GlucoDay Glucose Monitor
The Glucoday® S

Only the size of a portable audio device like a Walkman tape player, this device features: a one point calibration per 48 hour monitoring period, wireless real-time display on instrument and pc, blind or displayed mode operation, alarm (buzzer or vibration) in case of hypoglycemia or hyperglycemia, less than 2 min delay in response time, long life on board biosensor (up to 6 months after the first use at room temperature) and an accessible data base.

GlucoDay® S consists of a micro-pump and a biosensor coupled with a microdialysis system. The micro-pump has a flow rate of 15-100 ul/min. Two flow rates can be used, one for cleaning or filling of the line and and a slower rate for a continuous feed of the perfusion solution. The biosensor is made of an electrode which is covered by three separate membranes. A cellulose acetate membrane, an enzymatic membrane and a polycarbonate membrane. All held together by a Teflon tubing. The device uses it's peristalic pump to administer a continuous flow of perfusion solution from a storage bag in the device through the subject via a microfiber inserted under the skin. The microdialysis system is 2cm of a hallow fiber which is glued to two pieces of nylon tubing, a pair of twisted tungsten wires are inserted through the center to prevent a collapse of the membrane. The solution then carries a glucose sample from the microdialysis system to the biosensor in the device. The biosensor reacts continuously and a proportional current signal is detected and displayed every second. The solution continues through the biosensor and is dumped in another storage bag for disposal.

Glucoday S Graph
The GlucoDay® S is specifically for clinical use. It is worn by the subject for a 48 hour period. After calibration of the device to the patient, a physician would then insert the microdialysis system into the patient. Going about their normal activities, GlucoDay® S records realtime glucose values for analysis by a health care team. It produces charts like the ones shown to the right.The main goal for the device is to chart an individuals daily glucose activity especially during sleeping hours. With this information the health care team and the patient can modify the insulin regimen in order to achieve better control patterns.

The GlucoDay® S is available for purchase in Austria, Belgium, Italy, France, Germany, Greece, the UK, Portugal, Spain, and the Netherlands. No release date for the US has been announced.

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